ABSTRACT
Objective: To evaluate the efficacy of Huisheng oral liquid combined with TACE for treatment of primary hepatic carcinoma (PHC) with meta-analysis. Methods: Literature on the treatment of PHC with Huisheng oral liquid combined with TACE in CNKI, Wanfang, VIP, Pubmed, EMbase and Cochrane Library were searched from the establishment of database to October 2018. Meta-analysis of the included articles was performed using Stata 15.0 software. Results: Eight literature were enrolled, including 535 patients with intermediate stage PHC, of which 270 patients were treated with Huisheng oral liquid combined with TACE (study group) and 265 patients were treated with TACE alone (control group). The objective response ratio (risk ratio [RR]=1.39, 95%CI [1.19, 1.63], P<0.01), disease control ratio (RR=1.13, 95%CI [1.04, 1.23], P<0.01) and improvement of Karnofsky performance status score (RR=1.64, 95%CI [1.36, 1.98], P<0.01) were all improved in study group. Conclusion: Huisheng oral liquid combined with TACE is effective and safe for treatment of PHC.
ABSTRACT
Objective To design a new integrated portable biliary internal-external drainage catheter carrying125 I seeds used for the treatment of malignant biliary obstruction lesions so as to achieve the dual curative effects of biliary drainage and brachytherapy. Methods A total of 15 patients with malignant obstructive jaundice, who were admitted to the First Affiliated Hospital of Zhengzhou University, China, during the period from September 2016 to January 2018, were enrolled in this study. Biliary stent implantation was performed in all patients, which was followed by insertion of a new integrated portable biliary internal-external drainage catheter carrying125 I seeds. The technical success rate, clinical success rate, complications, stent patency time and patient survival rate were evaluated. Results The placement of the drainage tube was simple and smooth, and the technical procedure was successful in all patients. One month after treatment, the bilirubin level was decreased significantly when compared with preoperative one (P<0.01), while the blood indexes and immunological indicators showed no obvious changes (P>0.05) . After treatment, 2 patients (13.3％) developed cholangitis and 2 patients (13.3％) had small amount of biliary bleeding, which returned to normal after symptomatic treatment. No severe complications such as perforation of bile duct, massive bleeding, radiation enteritis and radioactive source leakage, etc., occurred. The patients were followed up for 55-402 days, 6 patients (40.0％) developed biliary re-obstruction. The median patency time of stent was 255 days, and 6-month stent patency rate was 64.5％. Five patients died and 10 patients survived, the 9-month survival rate was 64.3％, the median survival time was 368 days. Conclusion By using the new integrated portable biliary internal-external drainage catheter carrying125 I seeds, the effects of bile drainage and brachytherapy can be simultaneously achieved. Preliminary clinical practice indicates that this new drainage catheter is feasible, safe and effective, although its long-term efficacy needs to be clarified with further follow-up observations and controlled studies.